Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products
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- 作者：Hana Jansová ; a ; Jan Bure&scaron ; a ; Miloslav Machá ; čeka ; Pavlí ; na Ha&scaron ; ková ; a ; Anna Jirkovská ; a ; Jaroslav Roha ; Qin Wangb ; Katherine J. Franzb ; Petra Kovaří ; ková ; a ; Tomá ; &scaron ; &Scaron ; imůneka ; Tomas.Simunek@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：BASIH ; boronyl salicylaldehyde isonicotinoyl hydrazone ; free acid form ; BSAL ; boronyl salicylaldehyde ; BSIH ; boronyl salicylaldehyde isonicotinoyl hydrazone-pinacol ester form ; DFO ; desferrioxamine ; DMSO ; dimethyl sulfoxide ; FAC ; ferric ammonium citrate ; ICL670 ; adeferasirox ; INH ; isoniazid ; L1 ; deferiprone ; PKIH ; di ; 2-pyridyl ketone isonicotinoyl hydrazone ; PRC ; pyrocatechol ; ROS ; reactive oxygen species ; SA ; salicylic acid ; SAL ; salicylaldehyde ; SIH ; salicylaldehyde isonicotinoyl hydrazone
- 刊名：Toxicology
- 出版年：2016
- 出版时间：28 March 2016
- 年：2016
- 卷：350-352
- 期：Complete
- 页码：15-24
- 全文大小：2910 K
文摘
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Fe prochelator BSIH is nontoxic, stable and does not interfere with Fe homeostasis.
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BSIH is activated by ROS to Fe chelator SIH that is prone to hydrolysis.
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Salicylaldehyde is the main decomposition product of SIH and BSIH.
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Salicylaldehyde retains chelating activity and significant cytoprotective properties.
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BSIH is promising compound with multiple active degradation products.
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