Regulation of excitability in tonic firing substantia gelatinosa neurons of the spinal cord by small-conductance Ca2+-activated K+ channels
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- 作者：Kun Yanga ; b ; c ; yangk@ujs.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ca2+-activated K+ channels ; Apamin ; 1-EBIO ; Spinal cord ; Pain
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：15-24
- 全文大小：1471 K
文摘
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The excitability of tonic-firing SG neurons can be modulated by SK channels.
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The two-way modulation of synapses by SK channels can be mimicked by high or low Ca2+ solutions.
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The excitability increases of SK channels are mediated by Ca2+ influx.
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Apamin-sensitive and -insensitive Ca2+-activated potassium channels modulate excitability by different pathways.
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SK channels in the dorsal horn are potential targets for novel therapeutic analgesics.
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