Construction of stabilized and tagged foot-and-mouth disease virus
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- 作者：Jeong-Nam Park1 ; Mi-Kyeong Ko1 ; Rae-Hyung Kim ; Min-Eun Park ; Seo-Yong Lee ; Ji-Eun Yoon ; Joo-Hyung Choi ; Su-Hwa You ; Jung-Won Park ; Kwang-Nyeong Lee ; Ji-Eun Chun ; Su-Mi Kim ; Dongseob Tark2 ; Hyang-Sim Lee ; Young-Joon Ko ; Byounghan Kim ; Myoung-Heon Lee ; Jong-Hyeon Park ; parkjhvet@korea.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Foot-and-mouth disease vaccine ; Stability ; Tag
- 刊名：Journal of Virological Methods
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：237
- 期：Complete
- 页码：187-191
- 全文大小：1143 K
文摘
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A hexa-histidine(6xHIS)-tag was expressed on the FMDV particle.
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A virus with acid resistance was produced by replacing VP1/VP2 amino acids.
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The stable/tagged antigen is stable under an acid condition of pH 6.0.
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Mice immunized with stable/tagged antigen after pH 6.0 treatment showed complete protection.
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