Modulated cellular delivery of anti-VEGF siRNA (bevasiranib) by incorporating supramolecular assemblies of hydrophobically modified polyamidoamine dendrimer in stealth liposomes
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- 作者：Nasim Golkara ; nassim_golkar@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Soliman Mohammadi Samania ; b ; smsamani@sums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Ali Mohammad Tamaddonb ; c ; amtamadon@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DSPC (PubChem CID ; 94190) ; DAPI (PubChem CID ; 2954) ; TNBS (PubChem CID ; 11045) ; Pyrene (PubChem CID ; 31423) ; HEPES (PubChem CID ; 23831) ; N ; N-diisopropylethylamine (PubChem CID ; 81531) ; DOPE (PubChem CID ; 9546757) ; G1 PAMAM dendrimer (PubChem CID ; 15314332) ; G2 PAMAM dendrimer (PubChem CID ; 58720429) ; Ethidium bromide (PubChem CID ; 14710)
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：20 August 2016
- 年：2016
- 卷：510
- 期：1
- 页码：30-41
- 全文大小：1943 K
文摘
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PEG-liposomes (Stealth liposomes) incorporating G2-Chol40% showed low particle size with high siRNA loading efficiency and high stability against extracellular matrix.
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Incorporation of G2-Chol40% micelles into PEG-liposome attenuated their cytotoxicity to a great extent.
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Anti-VEGF siRNA loaded PEG-liposomes incorporating G2-Chol40% was able to transfect cells efficiently and showed endosomolytic activity.
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A superior sequence-specific inhibition of VEGF secretion and SKBR-3 cell growth was achieved by anti-VEGF siRNA loaded PEG-liposomes incorporating G2-Chol40% in comparison to dendriplexes.
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