Differential expression and response to arsenic stress of MRPs and ASAN1 determine sensitivity of classical multidrug-resistant leukemia cells to arsenic trioxide
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- 作者：Jing Chen1 ; Jie Cheng1 ; Juan Yi ; Bei Xie ; Li Lin ; Zhuan Liu ; Huaishun Zhao ; Bei Wang ; Ziying Ai ; Yue Yang ; Hulai Wei ; MD ; weihulai@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arsenic-resistance ; Multi-drug resistance ; MRP1 ; MRP2 ; ASNA1 ; Leukemia cell
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：50
- 期：Complete
- 页码：116-122
- 全文大小：1754 K
文摘
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The expression of arsenic transporters, MRP1, MRP2 and ASNA1, correlates negatively with leukemia MDR cells’ ATO-sensitivity.
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ATO enhances and inhibits the transporters’ expression in arsenic-resistant and -sensitive leukemia MDR cells, respectively.
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The transporters’ expression and response to arsenic stress determine leukemia MDR cells’ ATO-sensitivity.
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