Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells
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- 作者：Elena De Falcoa ; 1 ; elena.defalco@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Roberto Carnevalea ; 1 ; roberto.carnevale@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Paganoa ; francesca.pagano@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Isotta Chimentia ; isotta.chimenti@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Luca Fianchinia ; fianchiniluca@hotmail.it" class="auth_mail" title="E-mail the corresponding author ; Antonella Bordina ; anto.bordin@libero.it" class="auth_mail" title="E-mail the corresponding author ; Camilla Sicilianoa ; camilla.siciliano@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Roberto Monticoloa ; roberto.monticolo@libero.it" class="auth_mail" title="E-mail the corresponding author ; Francesco Equitanib ; fequitani@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Albino Carrizzod ; albino.carrizzo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mariangela Peruzzia ; mariangela.peruzzi@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Carmine Vecchioned ; cvecchione@unisa.it" class="auth_mail" title="E-mail the corresponding author ; Speranza Rubattuc ; d ; speranza.rubattu@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Sebastiano Sciarrettaa ; d ; 1 ; sebastiano.sciarretta@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Giacomo Fratia ; d ; 1 ; fraticello@inwind.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endothelial progenitor cells ; Aging ; Doxorubicin ; Nox2 ; Cardiovascular diseases
- 刊名：Mechanisms of Ageing and Development
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：37-43
- 全文大小：1639 K
文摘
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Role of Nox2 underlying early senescence with doxorubicin in human EPCs is explored.
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Nox2 activity is involved in oxidative stress-induced increase in premature aging.
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Aged EPC dysfunctional biological properties can be restored by controlling Nox2.
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