pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation
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- 作者：Jiaxiang Chena ; 1 ; Fei Liua ; 1 ; Hui Lia ; 1 ; Stephen Archackib ; Meng Gaoa ; Ying Liua ; Shengjie Liaoa ; Mi Huanga ; Jiuxiang Wanga ; Shanshan Yua ; Chang Lia ; Zhaohui Tanga ; zh_tang@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Mugen Liua
- 关键词：pVHL ; the Von Hippel&ndash ; Lindau tumor suppressor protein ; ECV complex ; elongin B/C-Cul2-VHL protein complex ; PHD1&ndash ; 3 ; prolyl hydroxylase domain proteins 1&ndash ; 3 ; UPS ; ubiquitin proteasome system ; HIFs ; hypoxia inducible factors ; ROS ; reactive oxygen species ; HRE ; hypoxia response element ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; GST ; glutathione S transferase ; NEDD8 ; neural precursor cell expressed ; developmentally down-regulated 8
- 刊名：Cellular Signalling
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：27
- 期：11
- 页码：2314-2323
- 全文大小：1313 K
文摘
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CERKL is degraded via the ubiquitin–proteasome system.
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Hypoxia regulates CERKL at protein level by reducing its poly-ubiquitination.
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CERKL complexes with ECV ligase via pVHL.
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pVHL ubiquitinates CERKL for proteasomal degradation.
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pVHL regulates the oxygen dependent degradation of CERKL.
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