Suppressor of cytokine signaling (SOCS) 1 is down-regulated in renal transplant recipients with rejection
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- 作者：Tsai-Hung Wua ; h ; 1 ; Hui-Ting Leef ; 1 ; Chien-Chih Laib ; i ; An-Hang Yangd ; Che-Chuan Loongc ; Hsin-Kai Wange ; Chia-Li Yug ; Chang-Youh Tsaib ; h ; cytsai@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allograft kidney ; Antibody-mediated rejection ; Pro-inflammatory cytokines ; Suppressor of cytokine signaling (SOCS)
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：54-59
- 全文大小：512 K
文摘
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SOCS1 rather than SOCS3 or CIS is a house-keeping gene for maintaining the renal allograft tolerance state.
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Downregulation of SOCS1 may be regarded as a harbinger for development of renal allograft rejection.
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SOCS1 can be a biomarker for renal allograft tolerance; its regular measure may help detect early rejection.
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