A surface-mediated siRNA delivery system developed with chitosan/hyaluronic acid-siRNA multilayer films through layer-by-layer self-assembly
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- 作者：Lijuan Wua ; b ; Changlin Wua ; b ; Ph.Dclwu1314@sina.cn" class="auth_mail" title="E-mail the corresponding author ; Guangwan Liub ; Nannan Liaoa ; b ; Fang Zhaob ; Xuxia Yangb ; Hongyuan Qub ; Bo Penga ; Li Chena ; b ; Guang Yanga
- 关键词：siRNA delivery ; Layer-by-layer self-assembly ; Controlled-release ; Gene silencing effect
- 刊名：Applied Surface Science
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：389
- 期：Complete
- 页码：395-403
- 全文大小：4254 K
文摘
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We prepared Chitosan/Hyaluronic acid-siRNA multilayer as carrier to effectively load and protect siRNAs.
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The stability and integrity of the siRNA was verified in the siRNA-loaded films.
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The siRNA-loaded films showed good cells adhesion and gene silencing effect in eGFP-HEK 293T cells.
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This is a new type of surface-mediated non-viral multilayer films.
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