Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma
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- 作者：Estefaní ; a Torres-Vegaa ; Marí ; a Durá ; n-Morenob ; Manuel Sá ; nchez del Pinoc ; Yania Yá ; ñ ; ezd ; Adela Cañ ; eted ; Victoria Casteld ; Rogelio Ló ; pez-Cuevase ; Juan Jesú ; s Ví ; lcheza ; e ; Josep Dalmauf ; g ; h ; Francesc Graush ; José ; Manuel Garcí ; a Verdugob ; Luis Batallera ; e ; bataller_lui@gva.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：OMS ; Opsoclonus-myoclonus syndrome ; SCLC ; Small-cell lung cancer ; NMDA ; N-methyl-d aspartate ; GABA ; Gamma-aminobutyric acid ; EDTA ; Ethylenediaminetetraacetic ; PBS ; Phosphate buffer saline ; HEK ; Human embryonic kidney cells ; ELAV-like ; Embryonic lethal abnormal vision-Drosophila ; KIF21 ; Kinesin family member 21 ; Kv3.3 or 3.1 ; Shaw-potassium voltage-gated channel subfamily C member 3 or 1 ; AMPA ; Amino-3-hydroxy-5-methyl-4isoxazolepropionic acid ; LGI1 ; Leucine-rich glioma-inactivated protein 1 ; KCT
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：297
- 期：Complete
- 页码：98-102
- 全文大小：527 K
文摘
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We aimed to identify new cell-membrane antigens in paraneoplastic opsoclonus-myoclonus.
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Immunogold studies showed cell-membrane IgG deposits on SH-SY5Y neuroblastoma cells.
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Systematic immunoprecipitation experiments and proteomic analyses were used.
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20">Candidate antigenic pathways included Shaw family of voltage-gated potassium channels.
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