Synthesis, characterization and biological evaluation of ruthenium(II) complexes [Ru(dtzp)(dppz)Cl]+ and [Ru(dtzp)(dppz)CH3CN]2+ for photodynamic therapy
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- 作者：Hui-juan Yua ; Jiang-ping Liub ; Zhi-feng Haoa ; Jun Hea ; Ming Suna ; Sheng Hua ; Lin Yua ; gych@gdut.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hui Chaob ; ceschh@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Photodynamic therapy ; Photocytotoxicity ; Anticancer drugs ; Spectra titration ; Ruthenium complex
- 刊名：Dyes and Pigments
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：136
- 期：Complete
- 页码：416-426
- 全文大小：1884 K
文摘
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Two new ruthenium complexes have been synthesized and characterized.
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Complex 1 shows great photocytotoxicity towards Hela cells (IC50 = 1.9 μM).
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Complex 1 inhibits Hela cell proliferation by induction of G2M phase cycle arrest and cells apoptosis.
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