Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: A too simplistic explanation that does not take into account the nanoparticle protein corona
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- 作者：Valé ; rie Forest ; vforest@emse.fr" class="auth_mail" title="E-mail the corresponding author ; Jé ; ré ; mie Pourchez
- 关键词：Nanoparticle ; Protein corona ; Nanoparticle/cell interaction ; Cellular uptake
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：889-896
- 全文大小：687 K
文摘
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Positive nanoparticles/cell membrane interactions are privileged.
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It is supposedly due to favorable electrostatic interactions.
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But in biological media, proteins adsorb on nanoparticle, altering surface charge.
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Thus, protein corona adds a level of complexity in nanoparticle/cell interactions.
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It further impacts cellular uptake and biological behavior.
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