Carnauba wax as a promising excipient in melt granulation targeting the preparation of mini-tablets for sustained release of highly soluble drugs
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- 作者：Viviane Nart1 ; André ; O'Reilly Beringhs1 ; Maria Terezinha Franç ; a ; Brenda de Espí ; ndola ; Bianca Ramos Pezzini ; Hellen Karine Stulzer ; hellen.stulzer@ufsc.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Highly soluble drug ; Sustained release ; Carnauba wax ; Melt granulation ; Mini-tablets ; Apparatus 3
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：250-257
- 全文大小：429 K
文摘
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Carnauba wax was exploited as a novel excipient for melt granulation.
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Melt granulation improved tabletability and flowability of both captopril and metformin HCl.
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Sustained release of captopril was achieved by Ethocel™ at a 50% (w/w) concentration.
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Sustained release of metformin HCl was reached by film-coating (Kollicoat® SR 30D: Opadray® II).
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Carnauba wax assisted sustaining the drug release in conjunction with the polymers.
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