Comparison of ectopic bone formation process induced by four calcium phosphate ceramics in mice
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- 作者：Zhurong Tang ; Yanfei Tan ; Yilu Ni ; Jing Wang ; Xiangdong Zhu ; Yujiang Fan ; Xuening Chen ; Xiao Yang ; xiaoyang114@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xingdong Zhang ; zhangxd@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Calcium phosphate ceramics ; Osteoinduction ; Phase composition ; BMP2
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P2
- 页码：1000-1010
- 全文大小：2678 K
文摘
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Bone formation was observed in BCP2 (HA:TCP = 3:7) after 16-week muscle implantation.
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BCP2 had elevated density and the least increment of porosity examined by μCT.
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Multiple peaks were observed in temporal gene expression patterns, confirmed by IHC.
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BCP2 group showed earlier and higher peaks in BMP2, BMPR1A, and OPG expressions.
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Time and magnitude of gene expression peaks is crucial in osteoinduction process.
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