Fully glutathione degradable waterborne polyurethane nanocarriers: Preparation, redox-sensitivity, and triggered intracellular drug release
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- 作者：Ismail Omrani ; Niloofar Babanejad ; Hasan Kashef Shendi ; Mohammad Reza Nabid ; m-nabid@sbu.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Waterborne PU ; Redox-responsive ; Intracellular drug release
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：607-616
- 全文大小：2107 K
文摘
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A novel fully glutathione degradable waterborne polyurethane was developed.
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The waterborne nanocarrier with disulfide bonds in both hard and soft segment were developed for redox-triggered intracellular delivery of DOX.
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The polyester diol bearing disulfide bonds in the backbone was prepared by a polycondensation polymerization reaction.
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