Feasibility study of silica sol as the carrier of a hydrophobic drug in aqueous solution using enrofloxacin as the model

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• 作者：Meirong Song ; Junling Song ; Aimin Ning ; Baoan Cui ; Shumin Cui ; Yaobing Zhou ; Wankai An ; Xuesong Dong ; Gege Zhang
• 关键词：Silica sol ; Enrofloxacin ; Controlled release
• 刊名：Materials Science and Engineering: C
• 出版年：2010
• 出版时间：1 January 2010
• 年：2010
• 卷：30
• 期：1
• 页码：58-61
• 全文大小：337 K

文摘

The aim of this study was to determine the feasibility of using silica sol to carry a hydrophobic drug in aqueous solution. Enrofloxacin, which was selected as the model drug because it is a broad-spectrum antibiotic drug with poor solubility in water, was adsorbed onto silica sol in aqueous solution during cooling from 60 °C to room temperature. The drug-loaded silica sol was characterized by transmission electron microscopy, Fourier transform infrared spectrum, thermal gravimetric analysis and ultraviolet–visible light spectroscopy. The results showed that enrofloxacin was adsorbed by silica sol without degradation at a loading of 15.23 wt. % . In contrast to the rapid release from pure enrofloxacin, the drug-loaded silica sol showed a slower release over a longer time. Kinetics analysis suggested the drug release from silica sol was mainly a diffusion-controlled process. Therefore, silica sol can be used to carry a hydrophobic drug in aqueous solution for controlled drug delivery.