Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome

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• 作者：Kais Hussein ; Katharina Theophile ; Guntram Bü ; sche ; Brigitte Schlegelberger ; Gudrun Gö ; hring ; Hans Kreipe ; Oliver Bock
• 关键词：Myelodysplastic syndrome ; MDS ; microRNA ; miR-150 ; miR-155 ; miR-221 ; miR-222 ; MYB
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：March 2010
• 年：2010
• 卷：34
• 期：3
• 页码：328-334
• 全文大小：664 K

文摘

We investigated whether, in myelodysplastic syndromes (MDS), aberrant expression of miR-150/miR-221/miR-222 and their designated target mRNA molecules MYB, p27 and c-KIT may be involved in insufficient haematopoiesis. In a series of MDS (n = 52), an aberrant increase of miR-150 was found only in MDS with associated del(5q) (n = 9; p < 0.01). The mRNA expression of transcription factor MYB, the designated target of miR-150, was shown to correlate inversely with the miR-150 level. Acute leukaemia evolving from MDS (n = 11) showed significantly decreased levels of miR-221 but not miR-222. We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q).