TLR4 is a link between diabetes and Alzheimer’s disease
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- 作者：Nan-Qu Huanga ; Hai Jinb ; Shao-yu Zhoua ; c ; Jing-shan Shia ; Feng Jina ; jinfeng1115@zmc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：LPS ; lipopolysaccharide ; HSPs ; heat shock proteins ; HMGB1 ; high mobility group box-1 protein ; S100A ; S100 calcium-binding protein A ; mmLDL ; minimally modified low-density lipoprotein ; OxLDL ; oxidized low-density lipoprotein ; FFAs ; free fatty acids ; AGE-LDL ; advanced glycation end products-modified LDL ; FetA ; fetuin-A
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：234-244
- 全文大小：1928 K
文摘
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TLR4 is involved in the physiological and pathological progress of DM and AD respectively.
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In DM, chronic TLR4 activation may contribute to the insulin resistance.
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In AD, chronic long-term TLR4 activation may lead to Aβ deposition.
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TLR4 as a potential link between DM and AD is reviewed.
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TLR4 as a link of between DM and AD further explain the theory that AD is regarded as types 3 diabetes.
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