Alterations in anxiety and social behaviour in Npas4 deficient mice following photochemically-induced focal cortical stroke
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- 作者：T.S. Klarića ; 1 ; E.J. Jaehneb ; 1 ; S.A. Koblara ; B.T. Bauneb ; M.D Lewisc ; martin.lewis@sahmri.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; Bdnf ; brain-derived neurotrophic factor ; CUMS ; chronic unpredictable mild stress ; GABA ; γ-aminobutyric acid ; FST ; forced swim test ; MCAo ; middle cerebral artery occlusion ; Npas4 ; neuronal PAS domain-containing protein 4 ; OFT ; open field test ; PI ; preference index ; PSD ; post-stroke depression ; SEM ; standard error of the mean ; SPT ; saccharin preference test
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：29-37
- 全文大小：959 K
文摘
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Wildtype and Npas4 knockout mice were compared in behavioural and cognitive tests following photochemically-induced stroke.
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Spatial recognition memory is impaired in Npas4−/− and wildtype mice after stroke.
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Despair-like behaviour is reduced in both Npas4−/− and wildtype mice after stroke.
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Stroke leads to increased anxiety in Npas4−/− mice but not wildtype mice.
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Stroke leads to decreased sociability in wildtype mice but not in Npas4−/− mice.
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