Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral deficits in a mice model of Alzheimer’s disease
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- 作者：Kefeng Wua ; &dagger ; ; Xiang Gaob ; &dagger ; ; Baoyan Shia ; c ; Shiyu Chena ; c ; Xin Zhoua ; Zhidong Lid ; Yuhong Gand ; Liao Cuia ; d ; Jing xuan Kange ; Wende Lia ; c ; lwd@gdlami.com" class="auth_mail" title="E-mail the corresponding author ; Ren Huangc ; labking@sohu.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aβ ; amyloid β ; AD ; Alzheimer&rsquo ; s disease ; APP ; amyloid precursor protein ; EDTA ; ethylenediaminetetraacetic acid ; GFAP ; glial fibrillary acidic protein ; MAP2 ; microtubule-associated protein 2 ; n-3 PUFAs ; Omega-3 polyunsaturated fatty acids
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：333
- 期：Complete
- 页码：345-355
- 全文大小：2885 K
文摘
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Establishment of the APP/fat-1 mice model with enriched endogenous n-3 PUFAs.
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High n-3 PUFAs and high ratio of n-3/n-6 PUFAs delay the early symptoms of AD.
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Reduced Aβ protein deposition inhibits glial cells activation and neuronal apoptosis.
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