Chronic intermittent hybobaric hypoxia protects against cerebral ischemia via modulation of mitoKATP
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- 作者：Shixiao Zhangc ; 18132632922@163.com" class="auth_mail" title="E-mail the corresponding author ; Zan Guoa ; b ; phyguozan18@126.com" class="auth_mail" title="E-mail the corresponding author ; Shijie Yangd ; iamyangshijie@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Huijuan Maa ; b ; ankang001@126.com" class="auth_mail" title="E-mail the corresponding author ; Congrui Fua ; fucongrui@163.com" class="auth_mail" title="E-mail the corresponding author ; Sheng Wanga ; b ; wangsheng@hebmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yi Zhanga ; b ; zhyhenryphy@163.com" class="auth_mail" title="E-mail the corresponding author ; Yixian Liua ; b ; phylyx2004@126.com" class="auth_mail" title="E-mail the corresponding author ; Jie Huc ; huj3993@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CIHH ; chronic intermittent hypobaric hypoxia ; mitoKATP ; mitochondrial membrane ATP sensitive potassium channel ; 5-HD ; 5-hydroxydecanoate ; Cyt c ; cytochrome c ; Δψm ; mitochondrial membrane potential ; DND ; delayed neuronal death ; ROS ; reactive oxygen species ; HG ; histological grade ; ND ; neuronal density
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：635
- 期：Complete
- 页码：8-16
- 全文大小：4011 K
文摘
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CIHH pretreatment ameliorates learning and memory dysfunction and DND in hippocampus caused by ischemia.
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CIHH upregulates expression of mitoKATP with or without ischemia..
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5-HD abrogates neuroprotection of CIHH suggesting involvement of mitoKATP.
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