Intraoperative infusion of remifentanil induces postoperative mechanical allodynia and thermal hyperalgesia.

Intraoperative infusion of remifentanil increases ROS level and phosphorylation of NMDA receptor subunits in spinal dorsal horn.

Systemic pretreatment with ROS scavenger inhibits remifentanil-induced postoperative mechanical and thermal hyperalgesia.

Systemic pretreatment with ROS scavenger attenuates the phosphorylation of spinal NR1 and NR2B induced intraoperative infusion of remifentanil.