Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanism
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- 作者：Tao Luo ; luotao@ncu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qian-xing Zou ; Yuan-qiao He ; Hua-feng Wang ; Tao Wang ; Min Liu ; Ying Chen ; Bing Wang
- 关键词：Acrosome reaction ; Capacitation ; CatSper ; Intracellular Ca2+ concentration ; Matrine ; Sperm motility
- 刊名：Reproductive Toxicology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：69-75
- 全文大小：1998 K
文摘
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Matrine has no toxicity on testis development and spermatogenesis of male mice.
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Matrine inhibits motility, capacitation and progesterone-induced AR of mouse sperm.
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Matrine reduces mouse sperm intracellular Ca2+ concentration.
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Matrine decreases mouse sperm CatSper current.
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Matrine down-regulates the expression of CatSper genes in mouse testes.
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