Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: A randomized controlled study

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• 作者：Bin Feng^a ; Zhang-Jin Zhang^b ; ^{zhangzj@hku.hk" class="auth_mail" title="E-mail the corresponding author} ; Rui-Ming Zhu^c ; Guo-Zhen Yuan^d ; Li-Yuan Luo^e ; Grainne M. McAlonan^f ; Fang-Zhong Xu^a ; Jiong Chen^a ; Lan-Ying Liu^a ; Yang-Yang Lv^e ; Hei Kiu Wong^b ; Ying Zhang^a ; Li-Xia Zhu^c
• 关键词：Obsessive compulsive disorder (OCD) ; Transcutaneous electrical acupoint stimulation (TEAS) ; Transcutaneous electrical nerve stimulation (TENS) ; Serotonin reuptake inhibitors (SRIs) ; Cognitive behavioral therapy (CBT) ; Clomipramine
• 刊名：Journal of Psychiatric Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：80
• 期：Complete
• 页码：30-37
• 全文大小：790 K

文摘

Transcutaneous electrical acupoint stimulation (TEAS) is thought to have potential to treat obsessive-compulsive disorder (OCD).

Objective

The purpose of this study was to determine whether adding TEAS to cognitive behavioral therapy (CBT) and clomipramine would improve the efficacy of these conventional treatments in OCD.

Methods

In this randomized controlled trial, 360 OCD patients were assigned to receive TEAS combined with CBT plus clomipramine (Group A, n = 120), TEAS combined with CBT plus placebo (Group B, n = 120), and simulated (placebo) TEAS combined with CBT plus clomipramine (Group C, n = 120) for 12 weeks. The primary outcome was measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).

Results

OCD symptoms in all patients reduced over time, however Groups A and B had a significantly greater reduction in Y-BOCS total score and the subscale for obsession and compulsion between week 2 and week 12 compared to Group C. Groups A and B had similar scores on these measures. Both groups had significantly higher rates of clinical response than Group C (88.3% and 81.7% vs. 67.5%, respectively, p < 0.001); and higher rates of remission (30.0% and 22.5% vs. 9.2%, respectively, p < 0.001). Group B experienced fewer adverse events than the other two groups.

Conclusions

TEAS enhances the efficacy of conventional OCD interventions and avoids the adverse effects associated with conventional pharmacological treatment. It can be considered as an effective adjunct intervention for OCD.