Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine
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- 作者：Bing Xuea ; Elton C. Chenb ; Nan Hea ; Dao-Zhong Jina ; Li-Min Maoa ; John Q. Wanga ; b ; c ; wangjq@umkc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：D1 ; D2 ; Muscarinic receptor ; S845 ; Protein kinase A ; Caudate putamen ; Nucleus accumbens ; Positive allosteric modulator
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：57-65
- 全文大小：1136 K
文摘
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A dopamine (DA) D1 receptor agonist elevates GluA1 phosphorylation in the striatum.
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DA D2 receptors augment efficacy of the D1 receptor agonist.
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A positive modulator of muscarinic M4 receptors (M4R) inhibits D1/D2 synergy.
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D1/D2 synergy determines the number of GluA1 and PKA at extrasynaptic sites.
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