Positive allosteric modulator of GABAB receptor alters behavioral effects but not afterdischarge progression induced by partial hippocampal kindling
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- 作者：L. Stan Leung ; sleung@uwo.ca" class="auth_mail" title="E-mail the corresponding author ; Miao Jin1 ; Liangwei Chu ; Jingyi Ma
- 关键词：GABAB receptor ; CGP7930 ; Kindling ; Hippocampus ; Methamphetamine ; Locomotion ; Prepulse inhibition ; Auditory gating
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：154-164
- 全文大小：1881 K
文摘
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GABAB receptor modulator CGP7930 or vehicle was injected during hippocampal kindling.
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CGP7930 (5 mg/kg i.p.) decreased afterdischarge starting frequency but not duration.
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CGP7930 reduced kindling-induced loss in prepulse inhibition and auditory gating.
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CGP7930 reduced the hyperlocomotion induced by methamphetamine after kindling.
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GABAB receptor positive modulator alleviates seizure-induced psychotic symptoms.
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