Tetrahydroxystilbene glucoside attenuates MPP⁺-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation

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• 作者：Xiaobing Li ; Yan Li ; Jianzong Chen ; Jing Sun ; Xiaofeng Li ; Xin Sun ; Xiaogang Kang
• 关键词：Parkinson's disease ; Tetrahydroxystilbene glucoside ; MPP⁺ ; PC12 cells ; Apoptosis ; ROS ; JNK
• 刊名：Neuroscience Letters
• 出版年：2010
• 出版时间：8 October 2010
• 年：2010
• 卷：483
• 期：1
• 页码：1-5
• 全文大小：372 K

文摘

It is known that oxidative stress plays a major role in the progression of Parkinson's disease (PD). Previous studies have suggested that 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active component extracted from a traditional Chinese herb Polygonum multiflorum Thunb., has significant antioxidant and free radical-scavenging activities. This is the first study that investigated the protective effects of TSG against MPP⁺-induced apoptosis in PC12 cells and determined the underlying mechanism. The results showed that incubation of PC12 cells with TSG before exposing them to MPP⁺ could significantly decrease cell viability loss and reverse cell apoptosis in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated via the inhibition of ROS generation and modulation of JNK activation because TSG blocked ROS increase and JNK phosphorylation induced by MPP⁺. Taken together, these results indicated that TSG may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases such as PD.