Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression
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- 作者：Linling Quea ; Liu Hea ; Chenshu Yua ; Wencheng Yinb ; Liwen Mab ; Baoshan Caob ; caobaoshan0711@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Siwang Yua ; swang_yu@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nrf2 ; nuclear factor erythroid 2-related factor 2 ; G-CSF ; granulocyte colony-stimulating factor ; HSCs ; hematopoietic stem cells ; HPCs ; hematopoietic progenitor cells ; 3LL ; Lewis lung carcinoma ; RBC ; red blood cell ; DPPH ; 2 ; 2-diphenyl-1-picryl-hydrazyl ; TOSC ; total oxidant-scavenging capacities ; TAOC ; total anti-oxidant capacity ; LDCL ; luminol-dependent chemiluminescence ; PBMC ; peripheral blood mononuclear cells ; SCF ; stem cell factor ; CDDO-Me ; 2-cyano-3 12-dioxooleane-1 ; 9(11)-dien-28-oic acid
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：16 November 2016
- 年：2016
- 卷：262
- 期：Complete
- 页码：17-26
- 全文大小：1830 K
文摘
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Nrf2 deficiency deteriorated CTX-induced myelosuppression in vitro/in vivo.
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Nrf2 deficiency decreased antioxidant capacity of peripheral blood and bone marrow.
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Nrf2 deficiency impaired hematopoietic proliferating and colony formation ability.
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CDDO-Me Nrf2-dependently mitigated CTX-induced myelosuppression.
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