Abscisic acid influx into human nucleated cells occurs through the anion exchanger AE2

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• 作者：Tiziana Vigliarolo ; ^{tiziana.vigliarolo@edu.unige.it" class="auth_mail" title="E-mail the corresponding author} ; Elena Zocchi ; Chiara Fresia ; Valeria Booz ; Lucrezia Guida
• 关键词：Abscisic acid (ABA) ; Transport ; Anion exchanger proteins (AE) ; AE2-siRNA ; K562 cells
• 刊名：International Journal of Biochemistry and Cell Biology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：75
• 期：Complete
• 页码：99-103
• 全文大小：676 K

文摘

Abscisic acid (ABA) is a hormone conserved from cyanobacteria to higher plants, where it regulates responses to environmental stimuli. ABA also plays a role in mammalian physiology, pointedly in inflammatory responses and in glycemic control. As the animal ABA receptor is on the intracellular side of the plasma membrane, a transporter is required for the hormone’s action. Here we demonstrate that ABA transport in human nucleated cells occurs via the anion exchanger AE2. Together with the recent demonstration that ABA influx into human erythrocytes occurs via Band 3, this result identifies the AE family members as the mammalian ABA transporters.