Palmitoylation of D₄R was studied in relation to its role in receptor function.

The D_4-4 variant of D₄R was palmitoylated at residue C467 of the carboxyl-terminal tail.

Palmitoylation was required for D₄R surface expression, endocytosis, and signaling.

Switching the carboxyl-terminal tails of D₂R and D₄R reversed their palmitoylation-related functions.