Irisin reverses platelet derived growth factor-BB-induced vascular smooth muscle cells phenotype modulation through STAT3 signaling pathway
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- 作者：Haibo Songa ; d ; Jia Xub ; Nan Lvc ; Yuzhu Zhangd ; Fei Wud ; Huanjie Lia ; c ; Lei Shaod ; Qian Mud ; Fang Wangd ; Dongqi Tangd ; tangdq@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xu Fanga ; fangxu@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vascular smooth muscle cells ; Phenotype modulation ; Irisin ; STAT3
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：14 October 2016
- 年：2016
- 卷：479
- 期：2
- 页码：139-145
- 全文大小：1181 K
文摘
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Irisin prevents PDGF-BB-stimulated VSMCs dedifferentiation.
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Irisin inhibits VSMCs towards a proliferative synthetic phenotype induced by PDGF-BB stimulation.
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Irisin treatment further activates STAT3 in VSMCs.
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The effect of Irisin on VSMCs phenotype modulation might be STAT3-dependent.
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