Calotropin from Asclepias curasavica induces cell cycle arrest and apoptosis in cisplatin-resistant lung cancer cells
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- 作者：En-Pan Mo1 ; Rong-Rong Zhang1 ; Jun Xu1 ; Huan Zhang ; Xiao-Xiong Wang ; Qiu-Tong Tan ; Fang-Lan Liu ; Ren-Wang Jiang ; trwjiang@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shao-Hui Cai ; csh5689@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Calotropin ; Cell cycle arrest ; Apoptosis ; JNK ; A549/CDDP cells
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：710-715
- 全文大小：1243 K
文摘
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This is the first report revealing the anti-tumor bioactivity of M11 on A549 and A549/CDDP cells. And A549/CDDP cells are about 100 times more sensitive than A549 cells to M11 treatment.
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M11 induces cell cycle arrest at the G2/M phase in A549/CDDP cells.
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M11 triggers JNK-mediated apoptosis via the mitochondrial apoptotic pathway in A549/CDDP cells.
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