Atorvastatin and rosuvastatin improve physiological parameters and alleviate immune dysfunction in metabolic disorders
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- 作者：Sungwon Lee ; Youngjoo Lee ; Jiyeon Kim ; Jinho An ; Kwanghee Kim ; Heetae Lee ; Hyunseok Kong ; Youngcheon Song ; Kyungjae Kim ; kimkj@syu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atorvastatin ; Rosuvastatin ; Type 2 diabetes ; Immune restoration ; In vivo CTL assay
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1242-1247
- 全文大小：1078 K
文摘
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Low doses of atorvastatin and rosuvastatin restored inflammation-linked metabolic disorders related to type 2 diabetes.
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Low doses of statins significantly decreased serum TNF-α levels in DIO mice.
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Low doses of statins also normalized host immune functions such as antigen specific CTL killing and IgG production.
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