FGF and BMP derived from dorsal root ganglia regulate blastema induction in limb regeneration in Ambystoma mexicanum
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- 作者：Akira Satoh ; satoha@cc.okayama-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Aki Makanae ; Yurie Nishimoto ; Kazumasa Mitogawa
- 关键词：Limb regeneration ; Blastema induction ; FGF ; BMP ; Nerve factor ; Accessory limb model
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：417
- 期：1
- 页码：114-125
- 全文大小：2409 K
文摘
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Electroporation method into axolotl DRGs was established.
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Fgf8-AcGFP and Bmp7-AcGFP were electroporated into axolotl DRGs.
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Distribution of Fgf8/Bmp7-AcGFP was investigated in regenerating blastemas.
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Knockdown of Fgf8 and Bmp7 by dsRNA interference impaired blastema induction.
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Fgf8 and Bmp7 derived from DRGs are essential for blastema induction.
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