A combinative analysis of gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus
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- 作者：Qing Liua ; liuqing@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xinwen Wanga ; Yuan Liub ; Minghui Weia ; Lihua Chenc ; chenlh@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：OLP ; oral lichen planus ; DEGs ; differentially expressed genes ; SRGAP2 ; SLITROBO Rho GTPase activating protein 2 ; VAMP4 ; vesicle-associated membrane protein 4 ; LRRTM4 ; leucine rich repeat transmembrane neuronal 4 ; KDM5C ; lysine (K)-specific demethylase5C ; DEMs ; differentially expressed miRNAs ; GSEA ; gene set enrichment analysis ; MSigDB ; molecular signatures database ; PPI ; protein&ndash ; protein interaction ; DCs ; dendritic cells ; DCC ; deleted in colorectal cancer ; AP1 ; adaptor-related protein compl
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：61-65
- 全文大小：713 K
文摘
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A total of426 differentially expressed genes were obtained in OLP.
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A total of 467 differentially expressed miRNAs were identified in OLP.
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miR-362 was revealed as a key miRNA targeting SRGAP2, VAMP4, LRRTM4 and KDM5C.
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DEGs were significantly enriched in olfactory transduction and ribosome pathways.
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