DNA maintenance following bleomycin-induced strand breaks does not require poly(ADP-ribosyl)ation activation in Drosophila S2 cells
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- 作者：Layal Ishak ; Amandine Moretton ; Isabelle Garreau-Balandier ; Mathilde Lefebvre ; Serge Alziari ; Philippe Lachaume ; Fré ; dé ; ric Morel ; Gé ; raldine Farge ; Patrick Vernet ; patrick.vernet@univ-bpclermont.fr" class="auth_mail" title="E-mail the corresponding author ; Pascal Dubessay1
- 关键词：PARP ; poly(ADP-ribose)polymerase ; PARG ; poly(ADP-ribose)glycohydrolase ; PAR ; poly(ADP-ribosyl)ation ; SSB ; single-strand break ; DSB ; double-strands break
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：8-16
- 全文大小：2011 K
文摘
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Bleomycin-induced DNA breaks generate low PARylation response in S2 cells.
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Oxidative stress and DNA breaks involve differential PARylation response in S2 cells.
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PARG is essential for regulation of PARylation processes towards genotoxic stress.
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PARP is an actor of DNA maintenance in the lack of exogenous stresses.
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