New on-line separation workflow of microbial metabolites via hyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography
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- 作者：Xia Yana ; 1 ; Li-Juan Wanga ; 1 ; Zhen Wua ; Yun-Long Wua ; Xiu-Xiu Liua ; 2 ; Fang-Rong Changb ; Mei-Juan Fanga ; fangmj@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ying-Kun Qiua ; qyk@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Comprehensive two dimensional liquid chromatography ; Medium-pressure liquid chromatograph ; ÿ ; ; preparative high-performance liquid chromatography ; Chaetomium globosum SNSHI-5 ; Cytochalasan derivatives
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1033-1034
- 期：Complete
- 页码：1-8
- 全文大小：2070 K
文摘
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A new separation workflow of microbial metabolites was proposed.
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On-line separation based on application of analytical and preparative 2D-LC.
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Unheated and oxygen-free sample post-treatment method kept compounds away from structural transformation.
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Twelve cytochalasan derivatives, including two new compounds, were obtained with high purity in a short period of time.
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