Quantification of cefazolin in serum and adipose tissue by ultra high performance liquid chromatography-Tandem mass spectrometry (UHPLC-MS/MS): application to a pilot study of obese women undergoing cesarean delivery
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- 作者：Ryan Lillicoa ; Casey L. Sayrea ; b ; Daniel S. Sitara ; c ; Neal M. Daviesa ; Cynthia M. Barond ; Ted M. Lakowskia ; ted.lakowski@umanitoba.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cefazolin ; Mass spectrometry ; Adipose tissue ; Cesarean delivery ; Stable-isotope internal standard
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：1031
- 期：Complete
- 页码：94-98
- 全文大小：597 K
文摘
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The first UHPLC–MS/MS assay using a stable-isotope cefazolin internal standard.
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Cefazolin is extracted from adipose tissue using a hexane/buffer solvent extraction.
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Cefazolin concentrations in adipose tissue are half the minimum inhibitory concentration.
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The concentration of cefazolin was more than 26-fold higher in serum than adipose.
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