Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages
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- 作者：Yongkun Dua ; b ; 1 ; mututushen@163.com" class="auth_mail" title="E-mail the corresponding author ; Taofeng Dua ; b ; 1 ; taofengdu@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yunpeng Shia ; b ; ling.dongyi@163.com" class="auth_mail" title="E-mail the corresponding author ; Angke Zhanga ; b ; zhangangke1112@126.com" class="auth_mail" title="E-mail the corresponding author ; Chong Zhanga ; b ; leofighting@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuwen Diaoc ; d ; diaoyuwen@szu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guangyi Jinc ; d ; gyjin@szu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; En-Min Zhoua ; b ; zhouem@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PRRSV ; TLR7 ; Antivirus factor ; ISGs ; NF-κB
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：9-18
- 全文大小：2867 K
文摘
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TLR7 ligand (SZU101) prevents PRRSV replication in PAMs.
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SZU101 treatment activates NF-κB and induces antiviral cytokines and genes expression.
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Blocking the activation of NF-κB reverses the suppression effect of SZU101 on PRRSV replication.
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Inhibiting the proper subcellular localization of TLR7 using specific inhibitor reverses the anti-PRRSV effect of SZU101.
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Co-administration of SZU101 and PRRSV enhances the humoral and cellular immune responses against PRRSV antigens in mice.
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