Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO₂ nanoparticles

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• 作者：Jiangxin Wang^a ; Xiaoshan Zhu^b ; ^c ; Xuezhi Zhang^b ; Zheng Zhao^d ; Huan Liu^d ; Rajani George^e ; Jeanne Wilson-Rawls^e ; Yung Chang^a ; ^{yung.chang@asu.edu} ; Yongsheng Chen^b ; ^f ; ^{yongsheng.chen@ce.gatech.edu}
• 关键词：Acute toxicity ; Bioaccumulation ; Chronic toxicity ; Microarry ; Reproduction ; Zebrafish ; TiO₂ ; Nanoparticles
• 刊名：Chemosphere
• 出版年：2011
• 出版时间：April 2011
• 年：2011
• 卷：83
• 期：4
• 页码：461-467
• 全文大小：808 K

文摘

As common engineered nanomaterials, TiO₂ nanoparticles (nTiO₂) are usually perceived as non-toxic, and have already been widely used in many products and applications. Such a perception might have been shaped by some short-term studies that revealed no/low toxicity of nTiO₂ to cells and eco-relevant organisms. However, given the ultimate release of nTiO₂ into the aquatic environment, which can act as a sink for engineered nanoparticles, their long-term impact on the environment and human health is still a concern and deserves more research efforts. Here, for the first time, we demonstrate that chronic exposure of zebrafish to 0.1 mg L⁻¹ nTiO₂, can significantly impair zebrafish reproduction. For instance, there was a 29.5 % reduction in the cumulative number of zebrafish eggs after 13 weeks of nTiO₂ exposure. Thus, we provided timely information on indicating a serious risk of reproductive impairment of environments contaminated with low levels of nTiO₂ on aquatic organisms, leading to alterations in population dynamics and aquatic ecosystem balance, and thus warrants a careful scrutiny on toxicity assessment of nTiO₂, especially their long-term impact.