Four SNPs of INSIG2 were detected in a total of 264 Chinese buffalo individuals.
Four SNPs had significantly associated with 305-day milk yield or protein percentage in Murrah and Crossbred breeds.
The diplotype H1H1 showed significantly associated with 305-day milk yield in Murrah buffaloes.
Buffalo INSIG2 gene could be used as a candidate gene for buffalo breeding program.
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