Cross-protective efficacies of highly-pathogenic avian influenza H5N1 vaccines against a recent H5N8 virus
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- 作者：Su-Jin Parka ; 1 ; Young-Jae Sia ; 1 ; Jihye Kimb ; Min-Suk Songa ; Se-mi Kima ; Eun-Ha Kima ; Hyeok-il Kwona ; Young-Il Kima ; Ok-Jun Leea ; Ok Sarah Shinc ; Chul-Joong Kimd ; Eui-Cheol Shinb ; Young Ki Choia ; choiki55@chungbuk.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：HPAI H5N1 ; H5N8 ; Vaccine ; ADCC ; Cross-protection
- 刊名：Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：498
- 期：Complete
- 页码：36-43
- 全文大小：1377 K
文摘
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The cross-reactive HI titer between H5N1 and H5N8 viruses was only observed in Horse red blood cells.
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Clade 2.5 H5N1 vaccine provide attenuation of H5N8 virus replication and cross-protection in mice.
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This heterologous protections by H5N1 vaccines might be closely associated with ADCC.
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