Nuclear export signal of PRRSV NSP1α is necessary for type I IFN inhibition
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- 作者：Zhi Chena ; Shaoning Liua ; b ; Wenbo Suna ; Lei Chena ; Dongwan Yooc ; Feng Lid ; Sufang Rena ; Lihui Guoa ; Xiaoyan Conga ; Jun Lia ; Shun Zhoue ; Jiaqiang Wua ; wujiaqiang2000@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yijun Dua ; duyijun0916@163.com" class="auth_mail" title="E-mail the corresponding author ; Jinbao Wanga ; wangjb@saas.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PRRSV ; NSP1α ; Type I IFN ; Nuclear export signal (NES)
- 刊名：Virology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：499
- 期：Complete
- 页码：278-287
- 全文大小：3175 K
文摘
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NSP1α contains the NES and NSP1α nuclear export was CRM-1-mediated.
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NSP1α was shuttling between the nucleus and cytoplasm continuously.
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The nuclear export of NSP1α was necessary for its ability for type I IFN inhibition.
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NSP1α interacts with CBP, which implies the mechanism of CBP degradation by NSP1α.
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