Interleukin-18 promoter polymorphisms and risk of Parkinson's disease in a Han Chinese population

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• 作者：Xiang Xu^a ; Dequan Li^a ; Qing He^c ; Jing Gao^a ; Biao Chen^b ; ; Anmu Xie^a ; ^{xieanmu@163.com}
• 关键词：Parkinson's disease ; Interleukin-18 ; Polymorphism
• 刊名：Brain Research
• 出版年：2011
• 出版时间：24 March 2011
• 年：2011
• 卷：1381
• 期：Complete
• 页码：90-94
• 全文大小：187 K

文摘

The etiology of sporadic Parkinson's disease (PD) is not well established. Interleukin-18 (IL-18), a member of pro-inflammatory cytokines, might influence the risk of sporadic PD occurrence and development. In this study, two DNA polymorphisms at interleukin (IL)-18 promoter, −607C/A (rs1946518) and −137G/C (rs187238), were examined in sporadic PD patients in a Han Chinese population with 290 sporadic PD patients and 200 healthy controls. Direct sequencing was performed in 10 % of the samples to validate the genotyping results. The results revealed that for −607C/A polymorphisms, there were significant differences in genotype distribution between PD and control in the total sample (P = 0.017) and between LOPD and healthy-matched controls subgroup (P = 0.011). For −137G/C polymorphisms, there were no significant differences in genotype distribution and gender and age-related differences between PD and control in the total sample (P = 0.610). Results in this study revealed that the IL-18 607C/A polymorphism is a risk factor for sporadic LOPD in Han Chinese population, while IL-18 137G/C polymorphism is not a risk factor for sporadic PD in the Han Chinese population.