Changes in hormone and lipid levels in male patients with focal seizures when switched from carbamazepine to lacosamide as adjunctive treatment to levetiracetam: A small phase IIIb, prospective, multicenter, open-label trial
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- 作者：Christian E. Elgera ; christian.elger@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Michael Rademachera ; michael.rademacher@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Christian Brandtb ; christian.brandt@mara.de" class="auth_mail" title="E-mail the corresponding author ; Sami Elmouftic ; sami.elmoufti@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Peter Dedekend ; peter.dedeken@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Klaus Eckhardte ; klaus.eckhardt@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Frank Tennigkeite ; frank.tennigkeit@ucb.com" class="auth_mail" title="E-mail the corresponding author ; Marc De Backerd ; marc.debacker@ucb.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AE ; adverse event ; AED ; antiepileptic drug ; CBZ ; carbamazepine ; C-SSRS ; Columbia Suicide Severity Rating Scale ; CYP450 ; cytochrome P450 ; fT4 ; free thyroxine ; HDL ; high-density lipoprotein ; LDL ; low-density lipoprotein ; LEV ; levetiracetam ; SHBG ; sex-hormone-binding globulin ; T3 ; triiodothyronine ; T4 ; thyroxine ; TEAE ; treatment-emergent adverse event ; TSH ; thyroid-stimulating hormone
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：1-5
- 全文大小：297 K
文摘
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The switch from CBZ to lacosamide as adjunctive therapy to LEV was well-tolerated.
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Serum reproductive, thyroid, and lipid parameters were normalized at 8 weeks.
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Antiseizure efficacy appeared to be maintained.
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Further studies could confirm clinical utility.
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