Complement deposition induced by binding of anti-contactin-1 auto-antibodies is modified by immunoglobulins
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- 作者：Luise Appeltshauser ; Andreas Weishaupt ; Claudia Sommer ; Kathrin Doppler ; Doppler_K@ukw.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：IVIG ; intravenous immunoglobulins ; GBS ; Guillain-Barré ; syndrome ; CIDP ; chronic inflammatory demyelinating polyradiculoneuropathy ; MMN ; multifocal motor neuropathy ; PE ; plasma exchange ; ELISA ; enzyme-linked immunosorbent assay ; OD ; optical density ; CBA ; complement binding assay ; PBS ; phosphate buffered saline ; BSA ; bovine serum albumin ; HEK ; human embryonic kidney ; TMB ; 3 ; 3&prime ; 5 ; 5&prime ; -Tetramethylbenzidine ; SD ; standard deviation ; MRC ; Medical Research Council
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：84-90
- 全文大小：967 K
文摘
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Binding of contactin-1 autoantibodies induces complement deposition and activation.
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The highest complement deposition can be found associated with the IgG3 subclass of anti-contactin-1 auto-antibodies.
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IVIG inhibits complement deposition in a dose-dependent manner, but does not inhibit binding of auto-antibodies to contactin-1.
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