Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption
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- 作者：Zhifeng Qia ; b ; 1 ; Jia Liangc ; 1 ; Rong Panb ; Wen Donga ; Jiangang Shend ; Yirong Yangb ; Yongmei Zhaoa ; Wenjuan Shia ; Yumin Luoa ; Xunming Jia ; Ke Jian Liua ; b ; kliu@salud.unm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Blood&ndash ; brain barrier ; Brain ischemia ; Zinc ; Matrix metalloproteinases ; Tight junction proteins ; Cell death ; Microvessel
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：12-21
- 全文大小：1216 K
文摘
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Zinc greatly increased BBB permeability in vitro under OGD conditions.
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Ischemia triggers accumulation of zinc in microvessels of ischemic rats.
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Chelating zinc dramatically attenuated ischemia-induced BBB permeability.
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Zinc accumulation in microvessels activates the free radical-MMPs pathways.
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