Leucine improves growth performance of intrauterine growth retardation piglets by modifying gene and protein expression related to protein synthesis
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- 作者：Wen Xu ; M.D. ; Kaiwen Bai ; M.D. ; Jintian He ; M.D. ; Weipeng Su ; M.D. ; Li Dong ; Ph.D. ; Lili Zhang ; Ph.D. ; Tian Wang ; Ph.D. ; Twang18@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leucine ; Protein synthesis ; Protein degradation ; mTOR ; IUGR
- 刊名：Nutrition
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：32
- 期：1
- 页码：114-121
- 全文大小：626 K
文摘
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Intrauterine growth retardation (IUGR) piglets exhibited a slower rate of growth and protein synthesis.
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We treated the IUGR piglet with l-leucine.
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The gene expressions related to protein synthesis were evaluated.
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Leucine activated the mTOR signaling pathway and reduced muscle atrophy in IUGR piglets.
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