Peripheral blood mononuclear cells of patients with Indian visceral leishmaniasis suppress natural killer cell activity in vitro

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• 作者：Ganes Chakrabarti ; Anirban Basu ; Partha Pratim Manna ; Sumitra Bhattacharya ; S ; eep Sen ; Santu B ; yopadhyay
• 刊名：Transactions of the Royal Society of Tropical Medicine and Hygiene
• 出版年：1996
• 出版时间：September - October 1996
• 年：1996
• 卷：90
• 期：5
• 页码：582-585
• 全文大小：491 K

文摘

Peripheral blood mononuclear cells (PBMC) of patients with Indian visceral leishmaniasis (VL) suppressed the natural killer cell (NK) activity of normal human PBMC in vitro in a dose-dependent manner. Adherent monocytes, but not the non-adherent lymphocytes of VL patients suppressed NK activity through soluble mediators. The level of suppression seen in different patients was variable.