PUMA and survivin are involved in the apoptosis of HepG2 cells induced by microcystin-LR via mitochondria-mediated pathway
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- 作者：Junguo Ma ; Yiyi Feng ; Yang Liu ; Xiaoyu Li ; lixiaoyu65@263.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microcystin-LR ; HepG2 ; Apoptosis ; PUMA ; Survivin ; Mitochondria-mediated pathway
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：241-249
- 全文大小：1864 K
文摘
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MC-LR induced time- and concentration-dependent apoptosis in HepG2 cells.
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MC-LR-induced apoptosis was mediated via mitochondrial pathway.
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p53 and Bax play an important role in MC-LR-induced apoptosis.
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PUMA and survivin were found to be involved in MC-LR-induced apoptosis.
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